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patients Michael Jordan White Sox Jersey
WASHINGTON Welington Castillo White Sox Jersey , April 30 (Xinhua) -- U.S. researchers said Wednesday that it is possible to rebuild large amounts of muscles severely damaged in traumatic accidents or military wounds by implanted tissues of pig bladders.

Researchers from the University of Pittsburgh tested the experimental technique on five male patients, who had lost between 58 and 90 percent of limb muscle, and found that three of them had a 25 percent improvement in function.

"This new study is the first to show replacement of new functional muscle tissue in humans, and we're very excited by its potential," Stephen Badylak Tim Anderson White Sox Jersey , senior investigator at the University of Pittsburgh.

"These are patients who can't walk anymore, can't get out of a car, can't get up and down from a chair, can't take steps without falling. Now we might have a way of helping them get better," Badylak said.

Large amounts of muscle can be lost as a result of trauma Ron Santo White Sox Jersey , such as a car accident, a sports injury, or even an explosive device. There is no treatment for such volumetric muscle loss and native muscle is unable to regenerate to that extent, to fully recovery function and tissue volume. Instead, scar tissue can form to fill the gap.

Stem cells have been shown to help damaged tissue regenerate Robin Ventura White Sox Jersey , but in most cases, stem cells should be taken out, isolated and grown into the cell of choice, and then injected back into patients.

Badylak's team, however Paul Konerko White Sox Jersey , used the extracellular matrix (ECM) from pig bladders to attract stem cells to the site of injury to promote regrowth of muscle.

According to the researchers, pig bladder ECM has been used for many years as the basis for medical products for hernia repair and treatment of skin ulcers. It is the biologic scaffold that remains left behind after cells have been removed.

After first showing the ECM method worked in mice with severely injured hind limbs, the researchers started a clinical trial involving five men, all at least six months removed from the time of injury, and for whom surgery and physical therapy had proved unsuccessful.

Three of the patients were in the military; two had thigh injuries from bombs while one had an exercise-induced calf injury. The other two patients were civilians with calf injuries from skiing accidents.

Before surgery Ozzie Guillen White Sox Jersey , all patients completed a 12- to 16-week physical therapy program that focused specifically on their individual functional deficits. The program continued until their function and strength plateaued for a minimum of two weeks, with no signs of further improvement.

Then, the researchers surgically implanted a "quilt" of compressed ECM sheets designed to fill into their injury sites, and within 48 hours of the operation, the participants resumed physical therapy for up to 26 additional weeks.

The researchers found that three participants Nellie Fox White Sox Jersey , including the two who had thigh injuries and one who had a calf injury, were stronger by 25 percent six months after the surgery and that biopsies and scans all indicated that muscle growth had occurred.

One thigh-injured patient improved on the "single hop test" by 1,820 percent, and the other had a 352 percent improvement in a chair lift test and a 417 percent improvement in the single-leg squat test.

Two other participants with calf injuries did not have such dramatic results, but both improved on at least one functional measure and said they felt better.

"This work represents an important step forward in our ability to repair tissues and improve function with materials derived from natural proteins. There will be more options to help our patients Michael Jordan White Sox Jersey , " said study co-author Peter Rubin, chair of the department of plastic surgery at the University of Pittsburgh.

"We think it's remarkable that this approach was able to improve function among patients who were all well past the acute injury response phase and were not helped by the standard surgical procedures they had already had," Rubin added.

The findings were published in the U.S. journal Science Translational Medicine.

Planning to spend your vacations at any international location? In the excitement of spending vacations, people generally forget to check their essential documents like the passport and other documents. Many times it happened that the date on your passport gets expired and people are not aware of it. It is too late by the time they realize that their passport is expired and hence they have to cancel their trip. Hence, if you don’t want to face such situation Melky Cabrera White Sox Jersey , then you should check your passport before you plan for an international trip.

If your passport is expired, then you have to <"http:wwwpassportexpressinc">find out New York passport agency that can help you in renewing your passport. Generally, availing a renewed passport is a lengthy process but can be simpler if you contact any renowned online expedite service provider. Here are some steps that will help you to get a renewed passport:

1. First of all you have to deposit your expired passport to the expedite agency and to make it invalid they will punch a hole in it. Your expired passport will be returned back to you along with your new passport. Moreover, when you apply for passport renewal, make sure that your old passport is not mutilated or damaged.

2. After that you have to fill the Form DS-82 which is an application for the renewal of the passport. This form can be easily downloaded from the website of the expedite company and you can easily fill it and submit to avail your renewed passport. Further Luke Appling White Sox Jersey , you also have to submit an authorization letter signed by you to the passport agency.

3. Deposit two latest passport size photographs to the passport agency. Make sure the picture is the recent one and both the pictures are identical to each other.

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